Synergistic interactions between resveratrol and doxorubicin inhibit angiogenesis both in vitro and in vivo

Resveratrol is a polyphenolic compound which found in many nutrients including grapes, peanuts, raspberries, and apples. Anti-proliferative, anti-angiogenic apoptotic effects of resveratrol have been shown on various cancer cells. Doxorubicin considered as one the most effective anticancer agents reveals its antitumor activity by induction apoptosis inhibition angiogenesis. Our study reports for first time potent ability combination with doxorubicin to inhibit angiogenesis vitro vivo. The cytotoxic effect (1.56-100 μM), (0.01-0.92 µM) their were analyzed human umbilical vein endothelial cells (HUVECs) ATP assay. In was evaluated using tube formation assay HUVECs. vivo assessed chick chorioallantoic membrane (CAM) model fertilized chicken eggs. All test groups compared thalidomide positive control, three concentrations (10-5-2.5 µg/pellet) 2 µg/pellet concentration examined. data statistically. alone displayed inhibitory cell viability at higher doses. However, exhibited significant dose-dependent CAM well proliferation HUVECs control (±)-thalidomide. results suggest that novel strategy prevention treatment